Unitarity sets upper limits on partial-wave elastic and inelastic cross-sections, which are often violated by perturbative computations. We discuss the dynamics underlying these limits in the non-relativistic regime, namely long-range interactions, and show how the resummation of the elastic 2-particle-irreducible diagrams arising from squaring inelastic processes unitarizes inelastic cross-sections. Our results are model-independent, apply to all partial waves, and affect elastic and inelastic cross-sections, with extensive implications for new physics scenarios, including dark-matter freeze-out and self-interactions.