Genetic Framework of Cyclin-Dependent Kinase Function in Arabidopsis - ENS - École normale supérieure Accéder directement au contenu
Article Dans Une Revue Developmental Cell Année : 2012

Genetic Framework of Cyclin-Dependent Kinase Function in Arabidopsis

Moritz K. Nowack
  • Fonction : Auteur
Hirofumi Harashima
  • Fonction : Auteur
Nico Dissmeyer
  • Fonction : Auteur
Xin'Ai Zhao
  • Fonction : Auteur
Annika K. Weimer
  • Fonction : Auteur
Freya de Winter
  • Fonction : Auteur
Fang Yang
  • Fonction : Auteur
Arp Schnittger
  • Fonction : Auteur

Résumé

Cyclin-dependent kinases (CDKs) are at the heart of eukaryotic cell-cycle control. The yeast Cdc2/CDC28 PSTAIRE kinase and its orthologs such as the mammalian Cdk1 have been found to be indispensable for cell-cycle progression in all eukaryotes investigated so far. CDKA;1 is the only PSTAIRE kinase in the flowering plant Arabidopsis and can rescue Cdc2/CDC28 mutants. Here, we show that cdka;1 null mutants are viable but display specific cell-cycle and developmental defects, e.g., in S phase entry and stem cell maintenance. We unravel that the crucial function of CDKA;1 is the control of the plant Retinoblastoma homolog RBR1 and that codepletion of RBR1 and CDKA;1 rescued most defects of cdka;1 mutants. Our work further revealed a basic cell-cycle control system relying on two plant-specific B1-type CDKs, and the triple cdk mutants displayed an early germline arrest. Taken together, our data indicate divergent functional differentiation of Cdc2-type kinases during eukaryote evolution.

Dates et versions

hal-04383117 , version 1 (09-01-2024)

Identifiants

Citer

Moritz K. Nowack, Hirofumi Harashima, Nico Dissmeyer, Xin'Ai Zhao, Daniel Bouyer, et al.. Genetic Framework of Cyclin-Dependent Kinase Function in Arabidopsis. Developmental Cell, 2012, 22 (5), pp.1030-1040. ⟨10.1016/j.devcel.2012.02.015⟩. ⟨hal-04383117⟩
5 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More